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Usually about 40 to 70 of a dose is excreted in the urine, but for chlortetracycline, doxycycline, and minocycline, rather less is eliminated by this route since chlortetracycline and minocycline undergo metabolism, and doxycycline is excreted mainly in the faeces.

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Demeclocycline and minocycline penetrate the skin better than other tetracyclines and may be preferred for treatment of acne.

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